TRIMming SIV Transmission between Species
نویسندگان
چکیده
منابع مشابه
TRIMming SIV Transmission between Species
Human immunodeficiency virus (HIV), the virus that causes AIDS, did not originate in humans. Instead, the most common variant, HIV1, is thought to have originated as a simian immunodeficiency virus (SIV) in apes and to have jumped the species barrier from apes to humans sometime in the first half of the 20th century. Similarly, HIV2—a related but less virulent virus—arrived in humans after jump...
متن کاملModern-day SIV viral diversity generated by extensive recombination and cross-species transmission
Cross-species transmission (CST) has led to many devastating epidemics, but is still a poorly understood phenomenon. HIV-1 and HIV-2 (human immunodeficiency virus 1 and 2), which have collectively caused over 35 million deaths, are the result of multiple CSTs from chimpanzees, gorillas, and sooty mangabeys. While the immediate history of HIV is known, there are over 45 lentiviruses that infect ...
متن کاملTRIM5α and Species Tropism of HIV/SIV
Human immunodeficiency virus type 1 (HIV-1) infects humans and chimpanzees but not old world monkeys (OWMs) such as the rhesus monkey (Rh) and cynomolgus monkey (CM). HIV-1 efficiently enters cells of OWMs but encounters a block before reverse transcription. This narrow host range is attributed to a barrier in the host cell. In 2004, the screening of a Rh cDNA library identified tripartite moti...
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To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi) and mobilized more robust responses at 6 and 10 dpi. Our results suggest th...
متن کاملTrimming
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2010
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000463